Israel's existence is "an affront to humanity", Iranian President Mahmoud Ahmadinejad said on Friday in a televised speech given at Tehran University marking al-Quds Day.
"The Zionist regime is a malignant cancer," Ahmadinejad was quoted by Iranian media as saying. "As long as even one cell of it remains on Palestinian land, the same situation will continue in the future."
Al-Quds Day is traditionally held on the last Friday of the Muslim holy month of Ramadan to show solidarity with the Palestinians and protest Israel's control over Jerusalem.
Iranian media outlets reported that millions of people took part in demonstrations across the country on Friday, chanting anti-American and anti-Israel slogans.
"The Zionists want to spread," Ahmadinejad said. "The presence of Zionists on even one centimeter of Palestinian territory is dangerous."
The Iranian president spoke out against a two-state solution to the Israeli-Palestinian conflict, saying that this would open up an "opportunity for the Zionists to stay in the region for another hundred years."
"The existence of the Zionist regime on parts of the Palestinian land is a dangerous thing, not to mention their desire for a legally defined state. Zionist control even over a tiny percentage of Palestinian land is a negative thing," he said.
Ahmadinejad stressed that Western powers feel obligated to protect Israel and are not able to tolerate criticism of Israel. He stated that confronting Israel is an effort to "protect the dignity of all human beings."
Earlier this week, Iranian Supreme Leader Ayatollah Ali Khamenei said that Israel will eventually "disappear from the geographical landscape," adding that he hoped a Palestinian state would rise in its place.
"With God's help, this year as well the Iranian nation will punch the faces of the enemies of Islam on al-Quds Day," Khamenei was quoted by the Mehr news agency as saying during a meeting with veterans of the Iran-Iraq War.
"The light of hope will shine on the Palestinian issue, and this Islamic land will certainly be returned to the Palestinian nation, and the superfluous and fake Zionist [regime] will disappear from the landscape," Khamenei added.
Khamenei also accused the "Zionists and their supporters" of trying to make the world forget the Palestinian issue.
"The Palestinian issue is not a tactical issue for us, but an [important] Islamic principle," Khamenei added. "We want to save this Islamic state from the oppressive Zionist fingernails."