The patient's diseased heart was removed entirely and replaced with a unique artificial heart made of titanium, combined with animal-derived biological tissues and advanced sensors.

The complex operation took place on Sunday and lasted seven hours. It was carried out by a large team of cardiologists, heart surgeons, anesthesiologists, intensive care specialists, operating room nurses, and heart-lung machine technicians. The patient's diseased heart was completely removed and replaced with a special artificial heart made of titanium, incorporating biological tissues from animals and advanced sensors.

Video: Artificial Heart Implanted at Hadassah Ein Kerem | Hadassah Ein Kerem Spokesperson

The procedure was only possible after the Hadassah team underwent specialized training in France, where they learned the implantation technique from local heart surgeons and representatives of the French company that developed the device. Upon their return to Israel, the team trained additional medical staff to prepare for the surgery.

"This is a major milestone for Israel and required extensive coordination with the patient's health maintenance organization and the Health Ministry, with full support from Hadassah's management," said Prof. Ofer Amir, senior cardiologist and head of the Heart Institute at Hadassah, who led the effort over the past several months.

After securing initial approval and funding from Clalit Health Services, the team began the dual-track preparation: training the staff and preparing the patient for the complex procedure.

The patient, a resident of central Israel, had been suffering from severe heart failure and significant breathing difficulties for years. His condition was so dire that it posed a real risk to his life while waiting for a suitable donor heart. Following extensive testing, the medical team determined that he was a suitable candidate for the artificial heart, which offers a vital solution for patients whose entire heart—both ventricles—has failed.

"Until now, advanced heart devices implanted in Israel were essentially left-ventricle assist devices, which supported only part of the natural heart. These are not suitable for patients with total heart failure," Dr. Korach explained. "This is a historic moment. For the first time, we're offering a life-saving treatment to people whose hearts have failed completely."

During the operation, the artificial heart was prepared in one operating room, with artificial valves added to the device. In a separate room, surgeons removed the patient's heart and connected him to a heart-lung machine. Once the artificial heart was ready, it was implanted and connected to the patient's main blood vessels.

Initially, the patient was supported by an ECMO machine, which performs the functions of the heart and lungs. Gradually, doctors reduced the machine's output as the artificial heart took over, eventually disconnecting the patient entirely. The artificial heart began functioning on its own.

"I felt like I was witnessing the future," said Dr. Alexander Lifay-Diamant, head of adult open-heart surgery at Hadassah, who led the procedure alongside Prof. Rabia Asleh, head of the heart failure unit; Dr. Ayman Morar, a heart surgeon; and senior anesthesiologist Dr. Stoinova Ralitsa.

"Until now, even the most advanced devices were connected to the patient's existing heart. This was the first time in Israel that a device replaced the heart entirely. Watching it beat inside the patient's chest was an incredible moment. This is the future, and it can help many patients who die while waiting for a heart transplant."

The device was developed by French company CARMAT, represented in Israel by Tzamal Medical. A heart costs 1.6 million shekels (about $430,000), and in this case was funded by Clalit, where the patient is insured.

Dr. Korach noted that the implanted heart could provide the patient with at least two years of high-quality life while awaiting a transplant.

"In retrospect, we can be proud of the carefully planned mission, executed by a large team that worked in perfect harmony to achieve success," Prof. Amir concluded. "Thanks to cardiologists, heart surgeons, perfusionists, anesthesiologists, intensive care specialists, nurses, and technicians, we've given a man who had been suffering a new lease on life."

As of January, 109 people in Israel were waiting for heart transplants, and seven were awaiting combined heart-lung transplants, according to the National Transplant Center.

The post Medical breakthrough in Israel: Artificial heart implanted at Hadassah Ein Kerem appeared first on www.israelhayom.com.

In a medical first, doctors transplanted a pig heart into a patient in a last-ditch effort to save his life and a Maryland hospital said Monday that he's doing well three days after the highly experimental surgery.

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While it's too soon to know if the operation really will work, it marks a step in the decades-long quest to one day use animal organs for life-saving transplants. Doctors at the University of Maryland Medical Center said the transplant showed that a heart from a genetically modified animal can function in the human body without immediate rejection.

The patient, David Bennett, a 57-year-old Maryland handyman, knew there was no guarantee the experiment would work but he was dying, ineligible for a human heart transplant and had no other option, his son told The Associated Press.

"It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice," Bennett said a day before the surgery, according to a statement provided by the University of Maryland School of Medicine.

On Monday, Bennett was breathing on his own while still connected to a heart-lung machine to help his new heart. The next few weeks will be critical as Bennett recovers from the surgery and doctors carefully monitor how his heart is faring.

There's a huge shortage of human organs donated for transplant, driving scientists to try to figure out how to use animal organs instead. Last year, there were just over 3,800 heart transplants in the US, a record number, according to the United Network for Organ Sharing, which oversees the nation's transplant system.

"If this works, there will be an endless supply of these organs for patients who are suffering," said Dr. Muhammad Mohiuddin, scientific director of the Maryland university's animal-to-human transplant program.

But prior attempts at such transplants – or xenotransplantation – have failed, largely because patients' bodies rapidly rejected the animal organ. Notably, in 1984, Baby Fae, a dying infant, lived 21 days with a baboon heart.

The difference this time: The Maryland surgeons used a heart from a pig that had undergone gene-editing to remove a sugar in its cells that's responsible for that hyper-fast organ rejection. Several biotech companies are developing pig organs for human transplant; the one used for Friday's operation came from Revivicor, a subsidiary of United Therapeutics.

"I think you can characterize it as a watershed event," Dr. David Klassen, UNOS' chief medical officer, said of the Maryland transplant.

Still, Klassen cautioned that it's only a first tentative step into exploring whether this time around, xenotransplantation might finally work.

The Food and Drug Administration, which oversees such experiments, allowed the surgery under what's called a "compassionate use" emergency authorization, available when a patient with a life-threatening condition has no other options.

It will be crucial to share the data gathered from this transplant before extending it to more patients, said Karen Maschke, a research scholar at the Hastings Center, who is helping develop ethics and policy recommendations for the first clinical trials under a grant from the National Institutes of Health.

"Rushing into animal-to-human transplants without this information would not be advisable," Maschke said.

Over the years, scientists have turned from primates to pigs, tinkering with their genes.

Just last September, researchers in New York performed an experiment suggesting these kinds of pigs might offer promise for animal-to-human transplants. Doctors temporarily attached a pig's kidney to a deceased human body and watched it begin to work.

The Maryland transplant takes their experiment to the next level, said Dr. Robert Montgomery, who led that work at NYU Langone Health.

"This is a truly remarkable breakthrough," he said in a statement. "As a heart transplant recipient, myself with a genetic heart disorder, I am thrilled by this news and the hope it gives to my family and other patients who will eventually be saved by this breakthrough."

The surgery last Friday took seven hours at the Baltimore hospital. Dr. Bartley Griffith, who performed the surgery, said the patient's condition – heart failure and an irregular heartbeat – made him ineligible for a human heart transplant or a heart pump.

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Griffith had transplanted pig hearts into about 50 baboons over five years, before offering the option to Bennett.

"We're learning a lot every day with this gentleman," Griffith said. "And so far, we're happy with our decision to move forward. And he is as well: Big smile on his face today."

Pig heart valves also have been used successfully for decades in humans, and Bennett's son said his father had received one about a decade ago.

As for the heart transplant, "He realizes the magnitude of what was done and he really realizes the importance of it," David Bennett Jr. said. "He could not live, or he could last a day, or he could last a couple of days. I mean, we're in the unknown at this point."

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