Iran's Civil Aviation Organization on Saturday insisted the country's airspace was "completely safe" for airlines to fly through, the semi-official Tasnim news agency reported.
The announcement comes as some global airlines have been rerouting flights to avoid Iran-controlled airspace over the Strait of Hormuz and Gulf of Oman after the US aviation regulator barred its carriers from the area until further notice.
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The downing of the unarmed Global Hawk drone, which can fly up to 60,000 feet, was the latest in a series of incidents in the Persian Gulf region, a critical artery for global oil supplies.
Thursday's emergency order from the US Federal Aviation Administration came after Iran shot down a high-altitude US drone with a surface-to-air missile, sparking concerns about a threat to the safety of commercial airlines.
According to flight tracking applications, the FAA said the nearest civil aircraft was operating within about 45 nautical miles of the unmanned aircraft when it was shot down.
"There were numerous civil aviation aircraft operating in the area at the time of the intercept," the FFA said, adding that its prohibition would stay in place until further notice.
The FAA said it remained concerned about the escalation of tension and military activity that are in close proximity to high-volume civil aircraft routes as well as Iran's willingness to use long-range missiles in international airspace with little or no warning.
