The Palestinians fumed over the weekend following reports that the United States will move its embassy from Tel Aviv to Jerusalem within months.
The Palestinians claim the eastern part of the city as the capital of a future state, and Trump's move has also angered Arab political and religious leaders across the region.
"This is an unacceptable step. Any unilateral move will not give legitimacy to anyone and will be an obstacle to any effort to create peace in the region," said Nabil Abu Rudeineh, a spokesman for Palestinian Authority President Mahmoud Abbas.
Abbas has rejected U.S.-led Middle East peace efforts as "impossible" since President Donald Trump's Dec 6. decision to recognize Jerusalem as Israel's capital, and to move the U.S. Embassy there.
U.S. officials said Friday that the United States was expected to open its embassy to Israel in Jerusalem in May.
Abu Rudeineh said that the "only way to achieve peace, security and stability" was Abbas' proposal – outlined in his Feb. 20 address to the United Nations Security Council in New York – that there should be an international conference to kick-start the stalled peace process with Israel, including a "multilateral mechanism" to oversee it.
Hamas official Sami Abu Zuhri, said, "Moving the U.S. Embassy to Jerusalem is a declaration of war against the Arab and Muslim nation, and the U.S administration must reconsider its move."